How does it work

Technology

Bioactive polysaccharides

The unique bioactive polysaccharides from natural origin are developed in a collaboration with the departments of Molecular Cell Biology and the Free University of Amsterdam.


The bioactive polysaccharides help maintain the balance of microflora and can provide a solution to keep the udder healthy.



The two modes of action are physiological. The unique bioactive polysaccharides prevent the attachment of microbes to tissue by forming a physical block against the attachment of harmful microbes to tissue (anti-adhesion) and temporarily retaining harmful microbes in one place (clustering), preventing them from multiplying.

Dual mode of action

Anti-adhesion

Prevents harmful microbes from attaching to host cell tissues without harming the healthy microbiota

Clustering

Neutralizes harmful microbes through its clustering action

Anti-adhesion activity on various substrates in vitro

The microscopic pictures “Without polysaccharides” clearly show the colonization of the cells with bacteria. “With polysaccharides” presents pictures during incubation and shows almost no bacteria are bound to the tissue. This clearly indicates that bioactive polysaccharides are very effective in preventing colonization bacteria. About 80-90% reduction in microbial adhesion to poly-L-lysine and gelatin. About 60% reduction in binding to epithelial cells.

C. ALBICANS + POLY-L-LYSINE

Without polysaccharides

With polysaccharides

C. ALBICANS + GELATIN

Without polysaccharides

With polysaccharides

C. ALBICANS + EPITHELIALCELLS

Without polysaccharides

With polysaccharides

S. AUREUS + GELATIN

Without polysaccharides

With polysaccharides

This research was conducted with VU Amsterdam

Clustering effect

The microscopic picture “Without polysaccharides” clearly show the cells with many scattered bacteria. The two pictures “With polysaccharides” shows images where the bacteria are rapidly grouped together in clusters. This indicates that bioactive polysaccharides are very effective in causing the bacteria to cluster. The positive outcome is that the body can efficiently clean up the clustered bacteria.

Without polysaccharides

10 seconds after adding polysaccharides

1 minute after adding polysaccharides

s. typhimurium

Without polysaccharides

s. typhimurium

With polysaccharides

s. aureus

Without polysaccharides

S. AUREUS

With polysaccharides

This research was conducted with Hogeschool Utrecht

Clinically proven effective against the following bacteria

Escherichia coli

Staphylococcus aureus

Klebsiella pneumonia

Streptococcus agalactiae

Streptococcus uberis

Streptococcus dysgalactiae 

Pseudomonas aeruginosa

Enterobacter cloacae

Microbiota health

What happens when the microbiota are disturbed?

Imbalanced microbiota (dysbiosis) can lead to pathogen overgrowth and inflammation. Microbial adhesion is the first step in the process of infection.

Phase 1

Harmful microbes need to bind to host epithelial surfaces to cause an infection

Phase 2

Microbes use adhesin molecules to bind to receptors on host cells

Phase 3

Microbes binding to epithelial cells trigger an inflammatory response and cause discomfort

Phase 4

Infection occurs when harmful microbes multiply or invade tissues, worsening discomfort

A healthy microbiota is crucial for the immune system and host defenses

The beneficial microbiota are part of our primary defense system and perform several crucial functions

Prevent colonization by pathogens by competitive exclusion of available niches (colonization resistance)

Directly antagonize pathogenic bacteria (bacteriocins)

Stimulate development of the immune system and tissues (immuno-modulation)

Promotes and supports mucosal structure and function